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KMID : 0359320020420030321
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Korean Journal of Veterinary Research
2002 Volume.42 No. 3 p.321 ~ p.326
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Involvement of Nitric Oxide and Prostanoid on Photorelaxation in Pig Renal Artery
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Abstract
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The effect of nitric oxide synthase(NOS) inhibitor, N^G-nitro-L-arginine-methyl ester(L-NAME) and prostanoid synthesis inhibitor, indomethacin on the photorelaxation, when was exposed to the long-wave length UV-light, was examined on the precontraction by the phenylephrine in the isolated pig renal artery.
1. UV-light relaxed both with-endothelium and without-endothelium in the pig renal arterial ring contracted by the phenylephrine.
The magnitude of photorelaxation was dependent on the exposure time for UV-light.
2. UV-light induced relaxation was inhibited by L-NAME and indomethacin on the precontraction by the phenylephrine in the isolated pig renal artery.
3. UV-light induced relaxation was inhibited by methylene blue on the precontraction by the phenylephrine in the isolated pig renal artery.
These results suggest that UV-light induced photorelaxation may be due to cGMP involved both nitric oxide and prostanoid on the precontraction by the phenylephrine in the isolated pig renal artery.
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